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On the other hand, the modification within a multi-Leu core in combination with the incorporation of a C-terminal 4-amidinobenzylamide (Amba) residue yielded potent cyclic analogues.
Theranostic QDs act as nanoscale therapeutic delivery vehicles (NDVs), transporting therapeutic molecules selectively to their site of action, while avoiding their interaction with sensitive healthy tissues and their degradation or modification within a biological environment.
By employing a target protein that does not interact with endogenous bacterial proteins, the structural details of the specific interaction between these molecules can be observed in the absence and presence of post-translational modification within a cellular environment.
The percentage values for each modification within a peptide under investigation were summed and divided by the number of hits.
To further test this hypothesis we introduced an AA modification within a single T8 loop in the C3T838 i-motif to give a loop composition of TTTAATTT.
Similarly, the source of an electrophile often dictates its potential protein targets, as the site of generation may promote modification within a subcellular microdomain.
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Importantly, the X-ray crystallographic analysis of 2′-azido uridine and 2′-azido adenosine modified RNAs reveals crucial structural details of this modification within an A-form double helical environment.
And we do not think it appropriate to bar, as Wyoming suggests, applications for modifications within a period of ten years, or alternately five years, from entry of the decree.
Using the SH3 domain of hematopoietic cell kinase as a test case, we show that SH3 binding properties can be profoundly altered by modifications within a hexapeptide sequence in the RT-loop region that is not involved in recognition of currently known consensus SH3 target peptides.
Both the Session Logging Tool and the Teacher Learning Goals instrument examine the facilitator's modifications within a session.
Parameter modifications within a plausible range did not change results markedly.
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