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Organism modification with time has been mainly explained by the production of free radicals as well as by immunological theories of aging.
These methods were used to measure the observed reaction rates for each adduction site by analyzing the extent of modification with time.
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Diamide shows an increase of overall modifications with time, whereas hydrogen peroxide shows a decrease of overall modifications with time.
Despite similar methods of oligonucleotide probe design, changes in the experimental procedure might explain the differences in transcript level estimates obtained using various platforms, and their modifications with time might be a source of the inconsistencies observed among experiments conducted by different laboratories and even in the same laboratory, when separated by long periods of time.
However, the possibility that lipid and lipoprotein modification might, with time, supplement these other strategies provides light at the end of the tunnel for further reducing this devastating complication of diabetes.
Most importantly, roNaV2 responds to blue light (470 nm) induced chemical modification with a time constant of about 300 ms, while roNaV1 was 1,000- and wild-type NaV1.4 even 10,000-times slower.
It is possible that transport was undertaken too early after treatment modification with insufficient time for stabilization, leading to a direct risk to the patient.
To ascertain whether spectral data modifications correlate with time we performed an OPLS regression.
Minimal sample handling and short-time extraction procedures are critical for large-scale metabolomic studies in order to achieve greater reproducibility and sensitivity and to prevent metabolite modification and degradation with time [ 14, 30].
The variation of supersaturation during immersion tests may also lead to a modification in deposited phase with time.
Longer oxidation times were not found to cause further changes in the region around Lys393A, whereas Lys399A exhibited further modification with increased oxidation times, which may result from secondary oxidation-induced conformational changes.
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