Sentence examples for modification which mediates from inspiring English sources

This process depends on the function of proteins of the Vps machinery and on RhoB posttranslational modification, which mediates its association with late endosomes.

Additionally, rhythmic binding of the CLOCK BMAL1 complex to DNA results in rhythmic chromatin modification, which mediates the rhythmic binding of other nearby transcription factors [ 15].

This modification, which mediates protein-membrane and protein-protein interactions, is characterized by the covalent attachment of a fifteen-carbon farnesyl or twenty-carbon geranylgeranyl group to the cysteine residue of a carboxyl terminal CaaX motif.

Remarkably, they uncovered a potentially novel Rab1 modification, which was mediated by a different effector AnkX.

It was observed that 20% of cellular lncRNAs are associated with specific chromatin modification complexes, such as PRC2, which mediates histone H3 lysine 27 trimethylation (H3K27me3) [ 70, 71].

Binding of further ubiquitin molecules to the previous one enables formation of a polyubiquitin chain which mediates degradation while modification of proteins with only one ubiquitin molecule mediates signaling [11].

Polycomb repressive complex 2 (PRC2), which mediates the histone modification H3 lysine 27 methylation, has been suggested as a candidate for this role (Silva et al., 2003; Plath et al., 2003) and has been proposed to bind directly to Xist RNA (Zhao et al., 2008).

As recently reported, each of these FAS1 domains contains an N-terminal recognition site for γ-glutamylcarboxylase, which mediates the post-translational modification of glutamate to γ-carboxyglutamate [ 40].

Chromatin immunoprecipitation assays indicated that EZH2 could directly bind to the SPRY4-IT1 pregionr region (−192 to −362 bp) and mediate H3K27me3 modification, which was supported by the fact that knockdown of EZH2 expression reduced EZH2 binding and H3K27me3 modification.

Our results suggest an indispensable role of FIP37 in mediating m6A mRNA modification, which is required for maintaining the shoot meristem as a renewable source for continuously producing all aerial organs in plants.

PRC2 is a critical regulator of histone modification, which catalyzes the trimethylation of H3K27 to mediate gene silencing.