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Composite point estimates of efficacy (episodes of incontinence per 24-hour period, frequency, and voided volume) and safety (dry mouth, withdrawal, and dose modification) were calculated.
Furthermore, as gender was of interest as a potential effect measure modifier, gender stratification was considered for all analyses; Wald p values to evaluate the statistical significance of observed effect modification were calculated from models including a gender interaction.
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The optimal structural modification is calculated by combining eigenvalue sensitivities and eigenvalue reanalysis technique iteratively.
Basing on the measurements of the contact angles of the three liquids, and according to the Young equation and the Lifshitz van der Waals and Lewis acid base theory, the BAPC surface energy after the modification was calculated.
Enrichment of each histone modification is calculated over these categories over the entire gene unit as described earlier [ 58].
The abundance of each modification was calculated relative to two internal standards (Ψ and tA), with similar results.
The degree of modification was calculated using the fluorescein molar extinction coefficient = 68,000 M−1 cm−1 and the method provided by the vendor.
The changed epigenetic modification was calculated as the difference between the intensity of epigenetic marks in EPT1 cells versus EP156T cells and indicated as delta.
Within each expression percentile, the number of genes marked by a given chromatin modification was calculated and represented as a percentage of all the genes marked by this modification.
To do so, the degree of overlap between SYT-SSX2 and a given modification was calculated as a ratio of bases covered per 5kb bin upstream of the TSS or the ratio of bases covered in the gene body over the total number of bases in the coding sequence.
Based on experiment data, the minimum stiffness modifications were calculated.
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