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As the goal map modification, we examined all of the detected differences and corresponding portions in the learning material.
In addition to active modification, we examined representative silent modifications H3K27me3 and H3K9me2.
To further elucidate the structure of the α-DG post-phosphoryl modification, we examined how synthesis of the terminal LARGE glycan was initiated.
To determine whether MT1G expression is regulated by epigenetic mechanisms in thyroid cancer, such as promoter methylation and histone modification, we examined MT1G expression in 6 thyroid cancer cell lines by conventional RT-PCR.
To get an insight into the dynamic relationship between tyrosine phosphorylation and O-GlcNAc modification, we examined the tyrosine phosphorylation status all O-GlcNAc modified proteins (at http://www.phosphosite.org) that have been identified to undergo significant changes in O-GlcNAc modification in response to GSK-3 inhibition.
Finally, to assess the consistency of evidence for effect modification, we examined the stratified analyses and the interaction terms in models run separately for each region and in pooled analyses, excluding the Gipuzkoa region because heterogeneity across regions was mainly attributable to this region.
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To study alterations in broad modifications, we examined the longer regions represented in this microarray format (see Methods; Additional file 34).
For all the histone modifications we examined (H3 and H4 acetylation and H3 K4 and K9 methylation), the cytological patterns on the active and inactive X chromosomes in mutant MeCP2-expressing cells were indistinguishable from those in clones expressing the wild type allele or in other control cultures (Fig. 1).
Alternatively, any or all of these three genes could be imprinted in opossum fibroblasts but not marked or regulated by the specific histone modifications we examined, or DMRs, but rather by some yet-to-be-identified genomic elements or regulatory mechanisms such as non-coding RNA transcripts.
For all the eight active histone modifications (we examined the subnuclear localizations of five of them as described above), less than 5% of the ChIP-seq peaks are within the sLADs and the peak densities in non-sLADs are substantially higher (about 10 to over 200 folds) than those in sLADs.
In order to address these problems without global protocol modifications, we examine link layer enhancement schemes.
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modification we investigated
modification we proposed
modification we mapped
modification we labeled
modification we inserted
modification we used
modification we performed
modification we asked
modification we stratified
modification we achieved
modification we conducted
modification we compared
modification we identified
modification we established
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