This modification is induced by formaldehyde (Toews et al., 2008), and has been recently detected in other datasets (Menschaert et al., 2009).
Furthermore, it will allow researchers to test if this inhibitory proteasome modification is induced or increased specifically in cells sensitive for proteasome inhibitors.
It is not clear whether PKC is linked to H3K56 acetylation in mammals but this modification is induced by replicative stress and its deposition is mediated by p300/CBP, the functional homologue of Rtt109 (Das et al., 2009; Vempati et al., 2010).
Moreover, different metabolic modifications are induced, such as reductions in unsaturated fatty acid contents and increases in the permeability of cell membranes, which collectively reduce plant performance (Bracale and Coraggio 2003; Tong et al. 2005; Miura and Furumoto 2013).
Chemical surface modifications were induced by UV-irradiation in a specially designed climatic chamber and were investigated through comparative tests on untreated and artificially weathered samples using X-ray photoelectron spectroscopy (XPS).
cDNA-AFLP (complementary DNA-AFLP) and MSAP (methylation sensitive amplified polymorphism) analyses were carried out on both leaves and tubers of one selected Cv to estimate if any transcriptome alterations or epigenetic modifications were induced by the two kinds of fertilization, however no variations were detected.
To determine if similar epigenetic modifications are induced by long-term culture of fibroblasts, we have compared DNA methylation profiles of passage 3 and passage 21 of fibroblasts (6 year old donor, othoplastic).
Many thousands of DNA modifications are induced daily in each cell through reactive oxygen species (ROS), formed as a by-product of aerobic metabolism, in contrast to the much lower levels of DNA damage induced at low doses of ionizing radiation.
However, dissecting the direct functional roles of Setd8 in DNA compaction in the epidermis is hindered by the fact that loss of Setd8-mediated deposition of H4K20me1 led to further changes of other histone modifications: H4 acetylation was induced and deposition of H4K20me3 was blocked.
