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Like Borlaug, who remained an outspoken supporter of genetic modification up until the end, Bill Gates is a believer in the power of science to tackle the ever-evolving problems that confront humanity.
All samples exhibited negligible surface modification up to at least the first 5 min of the MHz sonication.
Thus, we have demonstrated that the implantation resulted in semiconductor surface modification up to the nanoscale pattern formation.
The IC50 of both 2′-O-Me and 3′-deoxy ATP was decreased with the boranophosphate modification up to 16-fold.
The number of acidic sites of the modified nanocatalysts was increased by the silica modification up to 2 wt.% of SiO2 and afterward decreased.
Selected ZFN pairs were tested for the ability to induce sequence changes in a Cel1 assay and we observed frequencies of genomic modification up to 18.7% at the endogenous hTERT locus.
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The modifications up to 1993 were estimated to have added £24m to the cost; the most recent modifications, another £92m, making £116m altogether, or £350 per gun, to put right all the things that were wrong when production began.
The analytical solution by the two-scale perturbation analysis with modifications up to the second order is shown to be a most economical solution to give a reasonably good prediction.
Subsequent dosing modifications (up to or decreased from 100 mg/kg) were permitted based on SpO2 and observed adverse events temporally related to efaproxiral administration.
Additionally, we mixed 2′-azido, 2′-fluoro and 2′- O-methyl modifications up to a number of seven within the antisense strand.
This approach builds on the MotifADE method published in 2004 and extends it with two modifications: up-regulated genes and down-regulated genes are tested separately and in addition, tests have been implemented to identify combinations of transcription factors that work synergistically.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com