Searching for an excessive number of modification types is thus unrealistic.
The kinetic signatures for each cytosine modification type are shown in Figure 1 as ratios of the average IPD value at each template position of the modified template relative to the unmodified control.
Although this modification type is not known to regulate RNA binding, at this location it presents the potential to do so by changing hydrophobicity, creating stearic hindrance or blocking the potential for acetylation.
In human CD4+ T cells, 39 histone modification types have been mapped and several histone mark combinations showed correlation with enhancers, yet no single mark is associated with more than 40% of enhancers [7].
Through clicking on the figure of ' Proteobacteria', the distribution of phosphoproteins for different modification residue types is shown.
U→C editing has been suggested only for primary miRNA (pri-miRNAs) [22], and other modification types have not been reported for pri-mRNAs and mature miRNAs.
The shape of the GBR utility function and its PF modification for various traffic types are depicted in Figure 7. Figure 7 GBR utility function for common traffic types.
We suggest that RNA modification types can be classified based on substitution patterns found in OMM sRNAs.
Among the modification types observed were those known to result from sample preparation, including carbamylation and carbamidomethyl, as well as those that can occur both in vitro and in vivo, such as methionine oxidation [ 47, 48] and asparagine deamidation [ 49- 51].
