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In all, 100 patients were recruited in phase 1 and 2 (as with modification to the guidelines, it was felt appropriate to include a large number of patients at this stage) and 50 patients in phase 3.
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Other modifications to the guidelines are more worrisome.
The second stage instrument (B) also encourages clinicians to reflect on contextual issues particular to the management of hypertension in general practice, and allows them to suggest potential modifications to the guidelines.
Other minor modifications to the Guidelines and interpretation of Schema categories were made during the formal annotation phase, whether raised by one or both annotators; these were again resolved by discussion, with final resolution left to the curator.
Developers may choose to make modifications to the guideline document before it is finalized and disseminated.
For example, the recent modification to the American Thoracic Society guidelines for the treatment of hospital-acquired pneumonia [ 10] considered contemporary resistance data.
This method will be published in the second half of 2014 as modification to the current ESUR guidelines.
The CONSORT and Practihc groups describe modifications to the CONSORT guidelines to help readers assess the applicability of the results Randomised controlled trials are used to assess the benefits and harms of interventions in health care.
We expect that, as this approach is employed with additional taxa, one of two outcomes will result: (i) it will be validated as a general approach or (ii) it will fail in particular cases, which will precipitate modification(s) to the guidelines and/or the criteria that improve generality.
Since then, there have been many local modifications to the original guideline as a result of developments in anaesthetic practice and changing patient population.
We review earlier guidelines on the information that is necessary from preclinical studies before a compound enters clinical trials, and propose modifications to these guidelines.
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