Although these modifications, to some extent, have proved successful they would be unsuitable as a method of expanding cells for use in cell-based repair therapies and, as such, monolayer culture is a limiting factor for chondrocyte efficacy.
This implies that this particular post-translational protein modification is to some extent conserved in S. aureus and L. lactis.
The proteome, however, is far more complex and diverse because of post-translational modifications (PTMs) and to some extent isoform variations.
Hence, even though histone post-translational modification and DNA methylation are to some extent interlinked [ 31, 59- 62], they could be disconnected in the case of the cold-response regulation of VRN-A1.
Modifications of the claims codes could address this issue to some extent, but such modifications are not easy to implement and uptake may be variable if reimbursement is not directly tied to the new codes.
While the structural implications of this modification on these interactions is understood to some extent for p53 [ 13, 59, 60, 62, 63] little is known about p63 and p73.
In established vineyards, growers could compensate for non-uniform canopy architecture to some extent with modifications to the trellis system and standard training practices.
This is the case to some extent with epigenetic modifications of DNA, yet overall this is not what we see.
Although the structural diversity and bioactivity preference of polyoxin are, to some extent, affected by such modifications, the biosynthetic logic for their occurence remains obscure.
An increasing body of evidence indicates that many crop agronomic traits are likely to be affected to some extent by stably inherited epigenetic modifications [ 3- 5].
We alleviated this concern to some extent by focusing on histone modifications associated with co-localized genes that undergo altered expression.
