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Nevertheless, histone acetylation is unlikely to be the sole chromatin modification to regulate the activation of replication origins and similar to the regulation of gene transcription may act in concert with a multitude of other chromatin modifications.
Epigenetics uses chromatin modification to regulate chromatin structure dynamically.
Phosphorylation is a major post-translational modification to regulate protein function.
Recently, acetylation is also considered as an important post-translational modification to regulate protein stability.
These observations confirm the important role of H. pylori in controlling histone epigenetic modification to regulate IL-10 expression.
Consequently, SIRT1 and HDAC3 mediated-PLZF deacetylation provides for rapid control and fine-tuning of PLZF activity through post-transcriptional modification to regulate gene expression and cellular homeostasis.
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O-GlcNAcylation-mediated mechanism is no exception, often in collaboration with other histone modifications to regulate the biological processes in cells.
Lineage-restricted cells generally have more condensed chromatin architecture than pluripotent stem cells which employ unique histone modifications to regulate the balance between pluripotency and differentiation [35].
We suggest that a solution to the paradox might lie in the use of other, Spc1-dependent post-translational modifications to regulate the DNA binding affinity of Atf1 (Figure 5A).
It is well known that CGIs are the crucial platform for epigenetic modifications to regulate transcription.
Histones in the chromatin undergo an array of post-translational modifications to regulate gene transcription.
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