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Further chemical modification to identify more chemically stabilized EP4-receptor selective agonists was continued.
To obtain robust results, avoiding dependency on a particular execution of the algorithm, this article introduces the following modification to identify the main clusters of the network in a robust way.
We examined ten genes involved in nucleotide salvage and modification to identify significant motifs common to their upstream regions.
We used the PELT procedure through the R package "changepoint" [ 14] without any modification to identify boundaries.
Global pathway comparison was conducted by comparing all pathways using a hypergeometric distribution method with a minor modification to identify the pathways with most significant aberrations.
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This suggests that the 4-position of the pyridine ring is an ideal site for chemical modifications to identify inhibitors with improved pharmacokinetic characteristics.
One section of the search strategy used synonyms and variants of "multiple risk behaviours" and "lifestyle modifications" to identify relevant studies.
In Step III, we combined all obtained modifications for each of the incorrect predictions and screened the sets of combined modifications to identify rational and consistent sets of metabolic modifications.
As no methods are currently available for distinguishing between in vitro and in vivo modifications, to identify PTCMs in STM that are biologically relevant we assumed such modifications would be conserved across closely related organisms.
The use of histone modifications to identify previously unknown regulatory elements, such as promoters and enhancers, has also aided our understanding of disease associated genetic variant in the genome [ 20, 21].
S-Carbamidomethylation at cysteine (+57.02 Da), NAPQI-induced alkylation at cysteine (+149.15 Da), and oxidation at methionine (+15.60 Da) were set as dynamic modifications to identify the spectra of adducted peptides.
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modification to shoehorn
modification to interface
modification to boost
modification to supply
modification to generate
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modification to ease
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modification to regulate
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