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The disclosed results suggested that the C4′-position of aminoglycosides such as kanamycin may be an ideal site for modification to gain new modifying enzyme-resistant aminoglycoside antibiotics.
As a very high affinity SA tag, AviTag was chosen, rather than alternatives such as the Strep-tag, despite its need for enzymatic modification to gain functionality.
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Because CIITA is dynamically regulated by multiple PTM's and the intertwined nature of these modifications has yet to be fully defined, it is important to decipher these modifications to gain a better understanding of the regulation of this critical adaptive immune protein.
This modification is intended to gain more insights on the exact shape of indifference curves in (m, o -space.
For example, after years of describing static chromatin modifications, we are beginning to gain a glimpse into the dynamics of nucleosome assembly and modification, the importance of chromatin remodelers, histone chaperones and transcriptional elongation complexes, and clarification of their roles in development and disease.
We therefore concluded that the upper band represents monoubiquitinated TRIM32 and that D487N and the RING-mut fail to gain this modification.
The ratings board had originally given the game an "adults only" rating, but Take2 made modifications, including blurring some details, to gain a "mature" rating, meaning that it is intended for players 17 and older.
The advantage of the approach is to gain, without modifications, an effective space-variance and data reduction.
The three reviewers all believe your manuscript is very interesting and appropriate for eLife, but some modifications are needed for it to gain acceptance.
Systematic modifications of 39 were carried out to gain potency and reduce molecular weight and lipophilicity.
Voltammetric data have been complemented with attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) in order to gain information on the modification of chemical bonds of the binder upon biological attack and the formation of copper complexes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com