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It also requires modification to explain why the spectral (light-absorption) and magnetic properties of coordinated metal ions generally differ from those of the free ions and why, for a given metal ion, these properties depend on the nature of the ligands.
We also established confident assignment of number and type(s) of modification to explain observed mass shifts in an additional 239 MS/MS spectra (i.e., ~6% of modification-containing spectra); however site(s) of modification could not be unambiguously derived from spectral evidence (Additional file 3 Table S5C).
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In [ 6], they use a combination of three histone modifications to explain the gene expression variation among genes with the same functional annotations.
As in Argentina, genealogy (descent with modification) seemed to explain the distribution and diversity of life on these recently formed volcanic islands more reasonably than did special creation.
However, this could be a necessary modification in order to explain the high-frequency radiation observed in the acceleration.
Although many craters on Titan appear to be modified by aeolian infilling, fluvial modification is necessary to explain the observed impact crater morphologies.
A simple model of the interface chemical modifications is discussed to explain a physical origin of the observed shear-induced finger instability.
These modifications may contribute to explain the lower plasma insulin and pancreatic insulin content observed in LP pups [11] as well as the 3 fold-higher apoptotic rate in islets from offspring of dams fed a low protein diet during early life [17].
Also, insights into structural variation, gene-gene and gene-environment interactions, and epigenetic modifications are likely to explain the so-called missing heritability.
These epigenetic modifications may help to explain the patterns of inheritance seen in asthma and how they interact with environmental factors [ 56].
However, current knowledge about histone modifications is not sufficient to explain the mechanistic role of histone modifications on gene regulation.
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