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Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.
It employs using genetic modification to alter the sensitivity of malignant or normal tissue to the effect of radiation [14 17].
The evidence of high-level oligomerization of the SUMO1-modified VHL (VHL-SUMOΔC4) in the in vitro cross-linking assay, suggests that VHL has a unique space structure and requires SUMO modification to alter its conformation before oligomerization.
Therefore, a role may exist for dietary modification to alter BML natural history.
Nonetheless, numerous research groups and companies are using genetic modification to alter industrial yeast properties.
Transcription is either controlled through the requirement for a set of factors to be present in sufficiently high numbers in the right cells at the right time, or via TF modification to alter their binding to DNA or each other.
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The impact of chemical modification on siRNA efficacy in vitro and the potential for employing such modifications to alter the pharmacokinetic properties of siRNAs is also summarized.
The versatility of hcAd vectors is been increased by capsid modifications to alter their tropism and by the incorporation into their genomes of sequences promoting chromosomal insertion of exogenous DNA.
Although a multitude of peptide modifications have been incorporated into PEG-based hydrogels to control enzymatic cleavage kinetics, exploit photouncaging chemistries, or act as functional sites for the introduction of new biochemical cues, our findings are the first that employ peptide modifications to alter the cross-linking behavior for mechanical control.
A study by Brown et al. calls for alternative approaches by targeting different histone modification pathways to alter other posttranslational modifications on histones such as H3S28 phosphorylation which can minimize the dominant negative effect of H3K27M (Brown et al. 2014).
Exploiting the existing natural diversity and using techniques such as mutagenesis, protoplast fusion, breeding, genome shuffling and directed evolution to generate artificial diversity, or the use of genetic modification strategies to alter traits in a more targeted way, have led to the selection of superior industrial yeasts.
More suggestions(14)
modification to changes
modification to spread
modification to entrap
modification to shoehorn
modification to interface
modification to boost
modification to supply
modification to generate
modification to meet
modification to ease
modification to improve
modification to regulate
modification to keep
modification to enhance
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