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Of course as with any vehicle modification, the converted vehicle is often wildly different from a non-modified example.
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The modifications converted the well-known triterpenoid (exhibiting weak antitumor activity) to derivative 12, which displays high antiproliferative activity toward cancer cells.
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Our data indicate that the single H3K9me3 modification is converted by the Aurora B kinase into a double H3K9me3/S10ph modification on a proportion of nucleosomes at repressed genes.
While the initial catalytic rate of the class I ligase was modest, additional engineering and modifications have converted the ligase to a limited polymerase, capable of acting on exogenous templates and comparable to at least some protein enzymes that catalyze similar reactions (Wochner et al. 2011).
This paper presents a statistical study on a neuro-inspired spike-based implementation of the Vector-Integration-To-End-Point motor controller (SVITE) and compares its deterministic neuron-model stream of spikes with a proposed modification that converts the model, and thus the controller, in a Poisson like spike stream distribution.
Upon activation of autophagy, the 18 kDa cytosolic LC3 (LC3B-I) undergoes proteolytic cleavage followed by a lipid modification and is converted to the 16 kDa membrane-bound form (LC3B-II), which is specifically localized to the autophagosomal membranes.
Amidation proved to be a simple and inexpensive modification that converted kyotorphin into an effective and safe analgesic molecule, very likely able to cross the BBB.
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