Sentence examples for modification the binding from inspiring English sources

However, despite this slight structural modification, the binding mode of 3 differs dramatically from that of the first inhibitor, but provokes less pronounced induced-fit adaptations of the binding cavity.

The review will also not cover strategies different from enzymatic modification of the toxin molecule such as modification of the binding site on the ribosome and active export.

PRMT6 dimethylates H3R2, and this modification alters the binding of several effector proteins that typically bind H3K4Me.

The incorporation of positively charged amino groups in PEI modification enhanced the binding capacity of the biosorbents for negatively charged arsenic species.

Flow cytometric analysis indicated that lipid modification enhanced the binding affinity of preS to hepatocytes, but not resulting from hydrophobic interaction.

Since it has been shown that this modification reduces the binding activity of annexin [8], and also, that all four domains present in anxA5 are necessary for optimal binding affinity [9], it is important to ensure that the binding properties of anxA5 are not impaired by these reactions.

Inactivation of a ligand binding site can result from absence of an antibody chain, inappropriate assembly, misfolding, or unexpected modification of the binding site, and will affect the response ratios.

PrfA is a member of the Crp/Fnr family of transcriptional activators, and members of this family appear to require post-translational modification or the binding of a small molecule co-factor for full activity [21] [23].

The effect of modification on the binding was tested for three different types of DNA junction.

This post-translational modification attenuates the binding of hGR to GREs and its ability to influence glucocorticoid-responsive gene expression.

SUMOylation is a revertible posttranscriptional protein modification involving the binding of small ubiquitin-like modifiers (SUMOs) to target proteins.