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Polyubiquitination is an essential posttranslational modification that plays critical roles in cellular signaling.
Phosphorylation is a post-translational modification that plays a significant role in diverse biological phenomena.
The remethylation cycle is essential for the systemic methyl donor supply, which is used for important biological processes, such as cytosine-5 methylation of genomic DNA, an epigenetic modification that plays an important role in maintaining genomic stability, chromatin structure, and in controlling transcriptional capacity [2], [9].
DNA methylation is an epigenetic modification that plays an important role during mammalian development.
Glycosylation is a protein post-translational modification that plays a major role in many biological and pathological processes [ 22– 22].
This is termed as γ carboxylation which is an irreversible posttranslational modification that plays a role in the effective functioning of blood coagulation factors.
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Reversible lysine acetylation is one of the most important protein posttranslational modifications that plays essential roles in both prokaryotes and eukaryotes.
DNA methylation is one of the main epigenetic mechanisms, alongside histone modifications, that plays a significant role in gene silencing [ 1], tissue differentiation [ 2], cellular development [ 3], X-chromosome inactivation [ 4], or genetic imprinting [ 5].
Early histone acetylation is strongly associated with regions that we have previously shown to be bound in early embryos by the maternally deposited transcription factor Zelda, suggesting that Zelda triggers a cascade of events, including the accumulation of specific histone modifications, that plays a role in the subsequent activation of these sequences.
Covalent histone modifications, notably methylation, are reversible posttranslational modifications that play key roles in chromatin structure, gene transcription and the epigenetic state of the cell (Martin and Zhang, 2005; Mosammaparast and Shi, 2010).
The IP is subject to a host of post-translational modifications that play a central role in regulating its function.
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