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Modification testing for several a priori factors of interest was also possible because of the large sample size.
After modification, testing and with approval from the DSI originator, we renamed the DSI as the CKD Symptom Burden Index (CKD-SBI), to reflect the utility of the instrument to measure symptom burden and to broaden its appeal to other researchers to assess symptoms in the non-dialysis CKD populations.
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The third modification tested was adjustment for total daily visits.
The second modification tested was lengthening the baseline period.
The fourth modification tested was increased minimum value for SD.
In contrast, no single histone modification tested here correlated with the distribution of centromeric nucleosomes.
The first modification tested was stratification by weekdays versus weekend days.
Nor was there any correlation between the levels of histone modification tested at Hoxb promoters and the longer-term progression of the RA-induced increase in transcription.
In this assay, PCNA, S-PCNA and Ub-PCNA stimulate equally well the Polδ-mediated D-loop extension, indicating that PCNA stimulates the primer extension activity of Polδ regardless of the post-translational modification tested.
The other protocol modification tested was to repeat the hybridization step with the notion that each round of successive hybridization will further enrich for the target sequence as a substantially simplified amplicon is hybridized in the second round.
State 4 was different from other states, because it was marked by all histone modifications tested in the study.
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