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These results strongly suggest that RGD modification successfully endowed adenovirus with αv integrin specific infectivity to endothelial cells, and that peptide modification per se was not responsible for directing the tropism of the virus.
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After the hit compound had been obtained, our modifications successfully increased TAK1 inhibitory activity and solubility, but metabolic stability was still unsatisfactory.
By process parameter optimization and formulation modification, we successfully extruded a meloxicam amorphous solid dispersion.
This study demonstrates that engineering specifications for environmental modification were successfully established.
Previous studies have shown that lifestyle modification can successfully prevent or delay development of type 2 diabetes.
The Monkman Grant relation and its modification were successfully used to correlate minimum creep rate, time to rupture, and strain at rupture data.
Recent advances in enzyme engineering have used a combination of these random methods of directed evolution with elements of rational enzyme modification to successfully by-pass certain limitations of both directed evolution and rational design.
These modifications have successfully extended the application range toward them with verified accuracy.
In addition, the overexpression of the acetyl-CoA carboxylase was also investigated several times in combination with other genetic modifications, and successfully enhanced FFA production [ 60, 106, 143].
RNAseq in combination with the analysis of epigenetic marks (histone modifications) was successfully applied for a comparative study to analyze gene expression during the phylotypic period of medaka and zebrafish development (Tena et al. 2014).
This modification was also successfully performed on dispersed hepatocytes and engineered hepatocyte sheets.
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