Sentence examples for modification states of from inspiring English sources

RNA molecules, such as long noncoding RNAs (lncRNAs), have critical roles in regulating gene expression, chromosome architecture, and the modification states of chromatin.

Consistent with this view, many remodelling complexes contain components that recognise specific modification states of histone tails.

In addition to DNA methylation, epigenetic modification states of histones are also implicated in oncogenesis.

Chromatin connectivity destabilizes this synergistic system and introduces bistability, illustrating state switching between opposing modification states of the model gene.

Hence, the intrinsic enzyme activity of HDAC8 is consistent with the correlations observed in the post-translational modification states of endogenous histone proteins.

These findings suggest a complex chemistry leading to different modification states of cytosine in DNA and allowing methyl-removal to unmethylated DNA (Nabel and Kohli 2011).

Eukaryotic linear motifs (ELMs) are short stretches of amino acids often located within intrinsically disordered regions, which have been shown to help the targeting of proteins to specific subcellular localizations, determining the modification state of proteins, or regulating protein activity in a context-dependent manner18.

Although the 5' cap-dependent scanning mechanism can account for the translational initiation of most mRNAs in eukaryotic cells, several viral and cellular mRNAs contain nucleotide sequences in their 5' non-coding regions that can mediate binding of ribosomes to the mRNA, regardless of the modification state of the 5' ends.

The plot shows the modification state of the pool of KaiC molecules in an oscillating reaction during three full cycles: KaiC phosphorylated only on T432 (green curve), KaiC phosphorylated only on S431 (red curve), KaiC phosphorylated on both sites (blue curve), and the total fraction of phosphorylated KaiC (black curve).

The histone modification state of the mir-200c cluster CpG island also shows cell type-specific differences that are closely linked to the expression state of miR-200c/141 in normal and cancer cells.

The modification state of each of these residues was analyzed by mass spectrometry, and nine out of the ten proline residues were found to be hydroxylated (Fig. 7E)- the lone exception was Pro-123.