But while loan modifications can entail reductions in a homeowner's interest rate or in the principal amount, industry executives acknowledged that many and perhaps most of the loan modifications so far simply stretched out the original repayment terms.
By and large, the highest density of modifications so far described occurs in histone H3, particularly on its tail.
Because of this, most of what we know about the distribution, role and function of histone modifications so far has been passed through an antibody as essential mediator.
Although Amadori-products are the major glycated modifications, so far most studies in vitro and in vivo have focused on the role of AGEs in diabetic complications.
The 2′-azido modification hence complements the existing set of ribose modifications so far used in siRNA technologies, however, with the major advantage that it brings in additional chemical reactivity.
More than a million borrowers had received modification offers so far, they said.
The function of this modification, which so far has not been reported in any other protein except eEF1A, is completely unknown.
The histone methyltransferases Suv39H1 and ENX2 are phosphorylated in vivo [15], [16], but the exact position, the regulation or the biological function of the modification has so far remained elusive.
Despite the physiological and evolutionary importance of this trait, the investigation of the genetic basis of its function and modification has so far remained limited.
