Sentence examples for modification sites have from inspiring English sources

Moreover, whether these post-translational modification sites have any clinical relevance is an intriguing question.

The reason for choosing this data for the evaluation is the following: 1) it was used by ChIPDiff [ 11] and is easily compared to our program; and 2) differential histone modification sites have been validated in the same study [ 18].

Multiple post-translational modification sites have been observed, yet there are still many unanswered questions regarding the precise roles of these modifications in controlling the contradicting functions of E2F1.

Using techniques such as Western blotting and mass spectrometry, increasing number of histone modification sites have been identified in mouse, yeast, Drosophila melanogaster, Tetrahymena thermophila and A. thaliana [ 1- 3].

Finally, we observed that Met-44, one of the major modification sites, has an important role in the activation of procaspase-3.

It is evident from Table 1 that relatively few post-translational modification (PTM) sites have been recorded, for example, as these tend to evolve rather quickly and are often not associated with the structurally conserved core segments of conserved domains, which constitute the bulk of CDD's alignment models.

For instance the number of pseudouridylation sites in Trypanosomes is estimated to be 70-80 [ 39], but to date only around 50% of snoRNAs involved in the modification of these sites have been found [ 40].

Based on the comprehensive analysis of these datasets by a wide array of modern bioinformatics tools it was concluded that disordered regions of PCD-related proteins are involved in a multitude of biological functions and interactions with various partners, possess numerous posttranslational modification sites, and have specific evolutionary patterns (Peng et al. 2013).

Out of two O-GlcNAc modification sites we have identified in PHB, Ser121 is conserved in PHB2 and corresponding residue in PHB2 is Ser135.

Notably, the expression of four snoRNAs (GGgCD20, GGgCD76, GGgACA10 and GGgACA43) that are predicted to guide modification sites that have been previously reported to lack potential guide snoRNAs was detected.

In contrast, only 6% (783 out of 12,614) of the non A-to-G modifications are significantly different for the same two tissues, with no clear tissue preference: 45% and 55% of these sites have higher modification levels in the GFL and the OL tissue, respectively.