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The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs.
This histone modification signature correlated almost universally with whether the gene was expressed in PBL or not.
This is consistent with this region co-localising with lowly expressed novel transcripts (see below), and having a histone modification signature of promoters.
Female EpiSCs, however, display the histone modification signature of X inactivation (Guo et al., 2009).
Based on the histone code hypothesis, we expect genomic loci that share functionality to have a common chromatin modification signature.
To quantify the modification signature of these peptides, their relative abundance was measured by spectral counting (Table 3).
Similar(43)
Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and non-coding RNAs (ncRNAs).
The histone modification signatures were most pronounced at the PBL-specific transcriptional start sites of MEST and PLAGL1.
To incorporate chromatin modification signatures as additive information, an additional filter is applied to remove predictions that are not supported by the histone evidence.
Microarray tiles containing DNA sequences for known regulatory elements and novel ones formed two distinct clusters with differing histone modification signatures.
We considered that any biases at 5' ends of coding sequences may be distinct from those across gene bodies, as they lie within close proximity to promoters which have unique histone modification signatures.
Related(18)
variation signature
modulation signature
change signature
alteration signature
modified signature
modify signature
changes signature
modification signatures
updated signature
modification step
modification factor
modification approach
modification rate
modification community
modification rule
modification master
modification index
modification unit
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