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Our conclusion is that rRNA base modification serves to fine-tune ribosome structure so as to best coordinate the structure of the molecule with its functional requirements.

This fundamental cellular architectural modification serves to compartmentalise transcription and translation and likely permitted the evolution of more complex mechanisms for regulating gene expression [1].

It is presently thought that rRNA base modification serves to fine tune the ribosome structure so as to optimize ribosome biogenesis and the various functions carried out by mature ribosomes.

It has been proposed that such modification serves to strengthen anticodon-codon interactions involving weaker A-U base pairs relative to those involving G-C base pairs [ 50].

Thus, SUMO1 modification serves to protect Smad4 or the NFkB (nuclear factor kB) regulator IkB α (inhibitory kB α) from ubiquitin-dependent degradation.

Similar(55)

And many bases are simply places where chemical modifications serve to silence stretches of our chromosomes.

Beyond defining proteins, the DNA bases highlighted by ENCODE specify landing spots for proteins that influence gene activity, strands of RNA with myriad roles, or simply places where chemical modifications serve to silence stretches of our chromosomes.

The growing calls from the Israeli security community for a return to peace talks with the Palestinian leadership in the West Bank on the basis of the 1967 borders, with modifications, serve to highlight the discrepancy between Netanyahu's policies and Israel's strategic needs.

Thus, these modifications serve to localize Pdro to DRMs.

The prevailing view is that rRNA base modifications serve to fine tune ribosome structure and function.

These findings represent a direct demonstration in support of the prevailing hypothesis that rRNA modifications serve to optimize rRNA structure for production of accurate and efficient ribosomes.

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