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A dose modification schedule according to a 3+3 design will be applied.
Hand-foot syndrome was common, but severe cases were successfully prevented through strict adherence to a predefined dose modification schedule.
In all studies, the per protocol dose modification schedule, if required, was reduction to 400 mg once daily, followed by additional dose reduction to a single 400 mg dose every other day, if necessary.
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A dose-modification schedule based on grade ⩾2 neurological or cardiac toxicity and grade 3 or 4 other toxicities was adhered to.
The intensity of side effects was always slight or moderate, all side effects disappeared spontaneously and none requested any modification of scheduled treatment.
A conference with the bank to continue negotiations on the loan modification is scheduled this month, Bohr said.
Predicting whether patients are likely to have a positive outcome following treatment at entry might allow suitable modification of scheduled treatment, possibly resulting in improvements in outcomes.
In this decision-making process, young and young-elderly patients with primary and/or intermediate CIRS stage can be considered fit for standard treatments, while old-elderly and/or secondary CIRS stage patients are not eligible for conventional treatments and should be considered for treatment modifications (dose, schedule), to properly balance safety and efficacy.
Most of the avoidance techniques are used in the airfields, including aircraft flight schedule modification, bird habitat modification and exclusion, wildlife removal, bird harassment, and making the airfield unattractive to birds.
This particular modification of the schedule is permitted only for 50-minute computer-based labs.
The reason for this modification of the schedule in these cases is the limited availability of computer lab space and TAs.
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