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Owing to the complexity of metabolic systems, however, achieving a desired metabolic state through genetic modification remains difficult.
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Thus, even in the ideal circumstances of a rigorous clinical trial, consistent adherence to lifestyle modification remains a difficult clinical challenge.
Since the metabolic and inflammatory reactions are simultaneous, the demonstration of interplay that is more than a simultaneous modification remains a difficult challenge.
While much knowledge will be gained using L. japonicus as a model system for legume gene function, the application of that knowledge to modification of soybean traits remains difficult.
In view of these complex relationships, prediction of functional effects of microRNA expression patterns on cell cycle regulation remains difficult, particular since activities of certain proteins involved are regulated by posttranslational modifications or heterodimerization.
But their task remains difficult.
Assessing the program's effect remains difficult.
"For now the situation remains difficult".
Of course, the security situation remains difficult.
So the choice remains difficult to explain.
And so levelheadedness remains difficult.
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