Sentence examples for modification reader from inspiring English sources

AIP1 interacts with ABAP1, a plant regulator of DNA replication licensing and gene transcription, with a plant histone modification "reader" (LHP1) and with non modified histones.

Protein modification reader domains should also be useful in a range of clinical settings, for example for molecular diagnoses and monitoring, but this potential remains untapped in clinical routine settings.

Besides the interaction with ABAP1, a negative regulator of DNA replication and transcription, here we have identified that AIP1 interacts in vivo with the plant histone modification "reader" LHP1 and with non-modified histones.

The most similar Agenet/Tudor domain structure (mentioned as number 1 in Fig.  6a) is present in the PHD Finger protein 1 (PHF1), a polycomb group (PcG) gene that is a histone modification reader known to specifically bind to histone H3K36me3 and to recruit the Polycomb Repressive Complex 2 (PRC2) in humans [ 41].

Proteins belonging to the Agenet/Tudor domain family are known as histone modification "readers" and classified as chromatin remodeling proteins.

It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.

In this work we investigated a family of chromatin remodeling proteins in plants, containing the Agenet/Tudor domain, described as histone modification "readers".

The Agenet and Tudor domains, together with the Chromatin-binding (Chromo), Bromo, Bromo-Adjacent Homology (BAH), PWWP (conserved Proline and Tryptophan) and Malignant Brain Tumor (MBT) domains are known as histone modification "readers" and present in many proteins classified as chromatin remodelers [ 2, 3].

Various enzymes that are responsible for labeling and erasing the histone modifications ("writers") and proteins that specifically recognize these modifications ("readers") play a key role in the process of translating the "histone code" [4].

Establishment of specific epigenetic signatures within the cell requires coordinated action of numerous enzymatic machineries responsible for deposition (writers) and removal (erasers) of epigenetic modifications, as well as protein complexes that recognize these modifications (readers).

In comparison, the utilization of proteomic methods to measure characteristic changes in histone modifications, epigenetic readers or chromatin-associated factors at the protein level, which could potentially be used for cancer diagnosis and prognosis, is somewhat lagging behind.