Sentence examples for modification rate of from inspiring English sources
Hence, under the given circumstances, plasmid transfection caused a CCR2 modification rate of 3%%, whereas indels within CCR2 were not detectable after LP transduction.
As there was no information available about the production rate of DA, the modification rate of ASYN and the degradation of DA, we decided to use as initial values the production and removal rates of Reactive Oxygen Species (ROS) and the rate of modification they induce on WT ASYN from [ 24] in order to obtain initial values for the rates of these reactions in realistic boundaries.
Here, we show that incorporation of tandem nuclear localization signal (NLS) repeats into the ZFN protein backbone enhances cell permeability nearly 13-fold and that single administration of multi-NLS ZFN proteins leads to genome modification rates of up to 26% in CD4+ T cells and 17% in CD34+ hematopoietic stem/progenitor cells.
In recent studies, zinc finger nuclease (ZFN -mediated genomic modification rates of 3% - 100% for specific genes have been reported in ZFN -mediatedabidopsis, and rat [ 4- 16].
Using a novel derivatization reagent and mass spectrometry based analysis strategy to monitor changes in the covalent modification rates of lysine residues between native and H2O2-induced oxidized forms of CN, multiple regions within the protein complex that undergo significant conformational perturbation upon oxidative modification have been identified.
Full length and truncated channels also differed in methanethiosulphonate (MTS) modification rate constants of an engineered cysteine at position 231 near the selectivity filter.
For example, after being oxidized for 15 min, the fold changes determined for the DMBNHS modification rate constant of Lys459A from peptide 451A-472A and 457A-472A were 1.44 and 1.54-fold, respectively, with a standard deviation of 0.08.
Surprisingly, when desferrioxamine was added at the beginning of the aggregation phase of LDL modification, the rate of the modification was actually increased.
Significant Z-scores then indicate regulatory motif modifications whose rate of change cannot be adequately explained by the background rate of substitution.
In most cases, both the functional effects of modification and the rate of modification were similar for negatively and positively charged MTS reagents.
In fact, there was no apparent difference between those mutations located proximal to TM8 compared to those proximal to TM9, in terms of the functional effect of modification or the rate of modification, suggesting that these two "limbs" of CL3 show approximately equivalent accessibilities to the cytoplasm.
