ADP-ribosylation is but one example of how posttranslational modifications can profoundly affect the function of proteins.
An alternative set of mouse models, beyond the naturally occurring lupus strains discussed above, consists of knockout or transgenic genetic modifications that profoundly affect a single susceptibility gene.
Agricultural modification of landscapes profoundly affects the habitat of endemic species.
Recent data also point to another pathway, other than covalent histone modification, which can profoundly alter a chromatin arrangement in aging cells.
Protein kinases act by transferring phosphate groups from ATP to the amino acid side chains of target proteins, a modification that often profoundly alters the biological activity of the target molecule.
It is shown that small modifications to alloy chemistry profoundly change the phases formed during natural ageing: Cu-rich clusters in the Li-lean alloy and the δ′(Al3Li) phase in the Li-rich alloy.
-, -, -,,,, Third, that mutations affecting post-translational modification of the CTD profoundly influence phenotype in a wide variety of distinct organisms.
Modification by aldehydophospholipids may profoundly change the molecular properties of polypeptides, including net charge, conformation, state of association, enzymatic and signaling functions and last but not least, biological recognition, e.g. by receptors and the immune system (see Sections 2 and 3) (Fig. 3).
Different chemical modifications, which can be introduced to obtain stabilized analogues, may profoundly change peptide affinity or specificity.
They also suggest that some critical envelope properties, like selective permeability, are profoundly altered upon modification of pathogen-associated molecular patterns, and that this represents a further adaptation to the host.
