Sentence examples for modification profiles in from inspiring English sources

At the single gene level we found many differences in histone modification profiles, in particular between monocytes and in vitro cultivated cells, which correlate with their transcriptional changes.

In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples.

Thus, comparisons of the MD-resistant and susceptible lines revealed innate differences in histone modification profiles in addition to variations induced by MDV infection.

Previously, we explored the genome-wide histone modification profiles in the human primary T cells extensively and sought the functional significance of specific domains with histone modification islands [ 3, 4, 17, 18].

The histone modification profiles in bin sizes of 100 bp between −1 and +1 kb along these elements are also observed to be different from the random set (Supporting Information, Figure S1, A and B, blue vs. red).

Our data describe several differences of H3K4me3 modification profiles in monocytes, macrophages and DCs but also suggest that the chromatin status of functionally important gene clusters is coordinately modified.

The results show that the histone modification profile in adult erythroid cells is dramatically different compared to E11.5 cells.

Each imprinted gene present in at least one study is listed in Additional file 1: Chromatin and expression states with its associated expression profile and/or histone modification profile in human ESCs, liver and pro-B cells (REH) in addition to mouse ESCs, neural progenitor cells (NPCs) and embryonic fibroblasts (MEFs).

For this purpose we focused on 5 active (H3K4me1, H3K4me2, H3K4me3, H3K9ac, H3K27ac) and 2 repressive (H3K9me3, H3K27me3) histone modifications profiles in NHEK cells that have been generated by the ENCODE consortium [ 31].

In order to assess the effects of adequate levels of selenium and folate supplementation on histone modifications profiles in the liver previously reported methods [ 70, 71] were modified in order to significantly increase the concentration of nuclear proteins by combining both the nuclear pellet and supernatant.

These cells also display cell type-specific chromatin modification profiles, particularly in polycomb-regulated H3K27me3 marked genes [ 16].