Sentence examples for modification patterns such from inspiring English sources

We also observed differences in histone modification patterns (such as H3K4me2 and H3K9me2) between the primary cell line HDF and the transformed cells HT1080 and LT690.

We propose that the epigenetic modification patterns, such as histone acetylation might have a role in CDH1 exon 8 alternative splicing regulations as well.

Regulation of genes by DNA methylation and miRNA appears to be interrelated as the function of Dnmts depends on histone modification patterns, such as H3K9 methylation and histone deacetylation.

The latter patterns are reminiscent of histone modifications commonly found at genomic regions consisting of transcriptionally silent genes in which widespread patches of defined histone modification patterns such as H3K9me3 or H3K27me are found [ 2, 5].

For example, the H3K27me3 modification has been associated with repression and the H3K4me3 marker with activation of gene expression [ 26], and therefore it is likely that allele-specific modification patterns such as those we found in cluster 2 (Table  1) may be reflected in the expression patterns of nearby genes.

Histone modification pattern such as histone H3 lysine 9 trimethylation (H3K9me3), which has a prognostic relevance in glioblastoma, has not been detected in meningiomas yet [ 35].

Such modification patterns may be spread along chromatin, as has been suggested for H3-K9 and H3-K27 methylandon and heterochromatin formation [80].

This is particularly effective when rapidly changing environmental forces require the modification of ongoing behavioral patterns, such as during locomotion or during risk-reward evaluations.

Furthermore, the 2′-azido modifications are compatible with 2′-fluoro and/or 2′- O-methyl modifications to achieve siRNAs of rich modification patterns and tunable properties, such as increased nuclease resistance or additional chemical reactivity.

Recently, ChIP-chip and ChIP-sequencing experiments have been accumulated to identify TF binding sites as well as survey the chromatin modification patterns at the regulatory elements such as promoters and enhancers.

The activity of functional genomic elements is associated with the state of the chromatin at these sites, such as histone modification patterns and access of transcription factors to DNA.