Treatment was continued until disease progression, unacceptable toxicity despite dose modification or patient withdrawal.
Treatment was discontinued when the patient had recurrence of disease or adverse reactions unable to be controlled by dose modification or temporary withdrawal of S-1.
Therapeutic modification was defined as the addition, change of class, or withdrawal of antimicrobial agents, chemotherapy, or steroids according to identification of an etiology or exclusion of a presumptive diagnosis [ 27].
No deaths, serious AEs, AEs leading to withdrawal or dose modification, or clinically relevant changes in any laboratory parameters, vital signs, or electrocardiograms were reported.
The following interactions with the physical landscape are identified: avoidance, adaptation, modification, and withdrawal.
The EAI assesses six common symptoms of addictive behaviors [14,15] (i.e. salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse) and has relatively high internal consistency and convergent validity with the Exercise Dependence Questionnaire [13,16,17].
He displayed no misuse of authority or withdrawal symptoms whatever.
I feel zero sickness, or withdrawal symptoms.
Not all withdrawal effects are evidence of true dependence or withdrawal.
