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Secretion stress is caused by compromised folding, modification or transport of proteins in the secretory pathway.
Protein x COTRANSPORTS a (b) WITH c (d) SLC17A5 cotransports Neu5Ac with H+ SLC6A12 cotransports GABA with 3Na+ and 2Cl- Protein x COTRANSPORTS a (b) WITH c (d) SLC17A5 cotransports Neu5Ac with H+ SLC6A12 cotransports GABA with 3Na+ and 2Cl- In Reactome, activation is used only to specify a conformational event that does not otherwise involve covalent modification or transport.
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An interactome is defined as a set of genes whose protein products are functionally linked together either by direct binding, regulation of activity, regulation of expression, promoter binding, protein modification or molecular transport [ 48].
With multivariate analysis, only PEEP > 6 cmH2OR(OR = 2.1 [1.2-3.8]; p = 0.01) and treatment modification for transport (OR = 2.8 [1.5-5.3]; p = 0.001) were found to be significant (Table 5).
With multivariate analysis, parameters that predicted major patient-related AE during transport were norepinephrine before transport (OR = 4.4 [1.9-10]; p < 0.001) and treatment modification for transport (OR = 3.3 [1.5-7.4]; p = 0.001).
With multivariate analysis, only PEEP > 6 cmH2OR(OR = 2.1 [1.2-3.8]; p = 0.01) and treatment modification for transport (OR = 2.8 [1.5-5.3]; p = 0.001) were found to be significant (Table 5).
In our model the parameter kdrug is the amalgam of these ARV-intrinsic factors and is the rate at which a drug acts on its target, reflecting not only binding to the target but also intracellular transport, modification, or other direct interaction between the drug and the target cell.
Given that frequency facilitation is closely correlated with LTD [ 60] in vivo and since proper A1 receptor function is essential for mossy fiber plasticity [ 20], any modifications of A1 receptor function or transport inhibition might partly contribute to reduced basal synaptic transmission, reduced frequency facilitation and impaired LTD in pro-aggregant animals.
The ability to infer levels of carnivore modification based on limb elements can provide faunal analysts with the tools to determine whether the taphonomic signals in the fossil record relate to carnivore modification, hominin transport of appendicular elements, or both.
In contrast, transcripts classified as involved in cell division and development, cell wall modification and transport were more induced or not as much down-regulated in the mutants compared to wt.
The different interactions between various components might involve the protection of an active substance from decomposition by enzymes, modification of transport across membranes of cells or organelles, evasion of multidrug resistance mechanisms among others.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com