Sentence examples for modification or inactivation from inspiring English sources

The direct modification or inactivation of antibiotics by specific enzymes (e.g., acetyltransferases, phosphotransferases) can be another resistance mechanism.

This could possibly lead to a modification or inactivation of PTEN function.

On the other hand, genetic redundancy (multiple genes with the same proteomic function potentially compensating for modification or inactivation of one of them [ 76]) in downstream defence lines, such as the removal of hydrogen peroxide, could provide 'evolutionary space' for alterations in peroxidase sequences to occur.

These results suggest that the flotillin-1-mediated inhibition of I K amplitudes cannot be attributed to a modification of I K activation or inactivation properties.

30, 31 This reflects the existence of some multifactorial components involving drug sensitivity, acceleration of drug efflux, activation, or inactivation of drugs, modification in drug targets and DNA methylation that contribute to drug resistance property.

This modification for transcriptional alterations involves exclusion or inactivation of nuclease activity followed by use of the targeting system fused to a modular effector domain and is known as epigenome editing.

S-nitrosylation of mitochondrial targets is associated with a degree of variability, inasmuch as this post-translational modification affects mostly tissues with high energy metabolism and can lead to protection or inactivation of enzymes.

Chemical modification and inactivation of aminoglycosides by many different enzymes expressed in pathogenic bacteria are the main mechanisms of bacterial resistance to these antibiotics.

Also in ricin the A-chain represents the enzymatically active component, leading to modification and inactivation of 28S ribosomal RNA [31].

A combination of modifications (such as acetylation, methylation, phosphorylation, ubiquitination and sumoylation), within specific amino acids in each histone type leads to gene expression or inactivation [10].

In vitro studies have suggested that oxaliplatin modulates axonal Na+ channel inactivation properties via slowing of inactivation kinetics or changing the voltage dependence of activation or inactivation [7] [10].