Sentence examples for modification of viral from inspiring English sources
Moreover, no differences were observed in growth rates between biotin kodevirions and their respective unlabeled counterparts at any of the post-infection time points in vitro, indicating than non-destructive non-covalent modification of viral membranes with FSL constructs do not affect viral replication fitness7.
Alternatively, physical or chemical modification of viral vectors with biomaterials can be employed to modulate the tropism of viruses or reduce inflammatory and immune responses, both of which may benefit transduction.
Adenovirus particles can be engineered to display exogenous peptides on their surfaces by modification of viral capsid proteins, and particles that display pathogen-derived peptides can induce protective immunity.
Another common modification of viral glycoproteins is the covalent attachment of fatty acids, usually palmitate (C 16:0) in a thioester-type linkage to cysteine residues located either at the cytosol-facing end of the transmembrane region or in the cytoplasmic tail (Veit, 2012; Veit et al., 2013).
Ubiquitin modification of viral protein has been implicated in virion egress as well as in protein turnover.
Coxsackievirus infection promotes protein ubiquitination, contributing to effective viral replication, probably through ubiquitin modification of viral polymerase.
Another important research interest is focused on identifying and mapping post-transcriptional modifications of viral mRNAs and determining how these "epitranscriptomic" modifications affect viral replication and pathogenicity.
The effect of this modification on viral infectivity is not well documented.
Additionally, the use of recombinant viruses often is limited by the adverse effects of modifications on viral replication and assembly.
This approach can be useful when stabilization of infectious clones by modification of a viral cDNA cassette is not the feasible or suitable alternative.
However, anionic exchange requires no modification of the viral vectors such as biotinylation or his-tagging and is fast, versatile and easy to scale up [ 11, 35, 36].
