(B) Modification of trigger factors and lifestyle and treatment of comorbid disorders did not improve the headache.
Important goals are individual identification and modification of trigger factors, stress management and prevention or at least reduction in the number of headache episodes through pharmacological and psychological interventions.
The presence of adult-oriented triggers, triggers that were not identified at all, as well as triggers with a low predictive value for harm, indicate a need for modification of trigger tools to the setting in which they are intended to be used.
This example shows that the modification of underlying trigger processes, notably extreme events, is complex and not always easy to distinguish from adaptation (Egli 1996; Smith 2004).
It requires a multifaceted approach, including lifestyle modifications, management of triggering factors, education, support, and behavioral therapy [4].
We speculate that the act of modification triggers destabilization of the base pairing, presumably involving some other type of activity.
The failure of post-translational modification of SLR1 protein triggered derepression of its downstream genes, including GAMYB, in HNIL(H143) (Fig. 2), leading to an increase in responses downstream of GA signaling, such as α-amylase activity in the endosperm of germinating seeds (Fig. 3 and Additional file 3: Figure S3).
In conclusion, posttranslational modification of PFK1 might trigger the most important change in the regulation of glycolytic flux in cancer cells and might have an important impact on the Warburg effect.
There is also some evidence that unfavorable modification of epigenetic regulation triggered by stressful conditions in early life can be partly abolished via favorable psychological climate in subsequent life [ 61].
b Possible modification of (a) due to triggering.
