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Another aspect that must be considered, that has not been proven, is modification of transport guided passage across the BBB which could be modified during the attacks.
The different interactions between various components might involve the protection of an active substance from decomposition by enzymes, modification of transport across membranes of cells or organelles, evasion of multidrug resistance mechanisms among others.
Furthermore, stress not only induced changes in transport factor distribution, but also upregulated post-translational modification of transport factors.
These results suggest that the mechanism of drug sensitivity modification by flunarizine is not related to modification of tumour blood flow, but may be mediated by modification of transport mechanisms that are differentially responsible for cellular uptake and retention of melphalan as compared with cyclophosphamide.
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Modifications of transport properties and associated time scales with increasing pressure are considered.
The physiological significance of changes of nucleocytoplasmic transport under stress conditions has been linked to perturbed protein shuttling within signaling cascades, structural modifications of transport machinery, including the nuclear pore complex (NPC), and evocation of cell death by apoptosis.
Finally, both of these drugs have many actions (PubMed search) and, while the present manuscript reports effects in vivo that could be the result of modification to transport and ambient levels of glutamate, this is correlative, not necessarily causal, and thus not terribly convincing. 1) The authors use mTOR phosphorylation as a measure for upregulated mTOR signaling.
Finally, both of these drugs have many actions (PubMed search) and, while the present manuscript reports effects in vivo that could be the result of modification to transport and ambient levels of glutamate, this is correlative, not necessarily causal, and thus not terribly convincing.
article °3 states that all modification of guided transport is considered as essential if safety demonstration is modified.
Genetic modification of Pi transport proteins are maybe the key in developing tolerance to both –P and ++P stress.
The modification of the transport sector by introducing electric cars is not economically viable under the current market conditions.
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