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Because of the poor number of AEs causing the discontinuation or the modification of therapy, data regarding the comparison of their proportion between the different treatments were not shown in the previous Table.
No differences were found in the proportion of AEs between lamotrigine and CBZ (p = 0.311), but a tendency in a higher number of AEs causing the discontinuation or the modification of therapy was seen for CBZ (p = 0.06).
PET/CT is effective for monitoring physiological response after one treatment, prior to pathologic confirmation at the time of surgery, and thus decisions regarding the continuation or modification of therapy can be made early in the treatment course [39].
All comparisons are summarized in Table 3. Considering the poor number of signaled AEs, no statistical comparisons were made between the different odds of AEs and AEs causing the discontinuation or the modification of therapy.
Modification of therapy for toxicity occurred at any time as clinically indicated.
For early modification of therapy, markers predicting therapy response are urgently required.
Similar(39)
The objective is to enable earlier aggressive treatment, through regular disease activity assessments and appropriate modifications of therapy, in order to achieve disease remission [ 6].
Despite the large availability of these treatments, approximately 50% of patients have persistence of active SLE or the occurrence of a relapse [ 9, 10] which both require modifications of therapy, most commonly with an increase of corticosteroid dosage and introduction of immunosuppressant drugs [ 8].
This likely reflects the close monitoring of individual patients within a relatively small clinical service where interpretation of minor symptoms and clinical markers (urinalysis, C-reactive protein, serum creatinine, platelet count, ANCA titre) in identifies minor disease relapses leading to modifications of therapy that potentially prevent more major disease activity.
Modification of AED therapy (addition or subtraction of therapies, and/or adjustment of dosage) was unrestricted throughout the study.
"No change" was defined as when empiric therapy was maintained without modification, "Escalation of therapy" was defined when there's a switch to or addition of an antibiotic with a broader spectrum, and "De-escalation" when there's a switch to or interruption of a drug class resulting in a less broad spectrum of coverage.
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