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ROS induce apoptosis in tumor cells also by modification of the activity of mitogen-activated protein kinases (MAPKs; EC 2.7.11.24) [149] and of the nuclear factor kappa B (NF-κB) [150].
The result of such binding is the modification of the activity of the partner, the assembly of a complex or local posttranslational modification of the IDP [14], [15].
In conclusion, treatment with PBBs resulted in modification of the activity of renal microsomal enzyme activities but had no detectable effect on renal function.
Modification of the activity of master regulators is a promising strategy for plant stress improvement that should increase the plasticity of the plant responses and adaptation as many genes and enzymes are under their control.
This genetic switch has been retained from the cyanobacterial ancestor of chloroplasts (Puthiyaveetil and Allen 2009) and is a transcriptional analog of posttranslational modification of the activity of photosystem I and II by phosphorylation of chloroplast light-harvesting complex II (Allen et al. 1981; Allen 1992).
Consistent with our findings, rats fed with mercury-contaminated rice produced near the Wanshan mercury mine in China were subjected to an oxidative stress materialized by an 87% increase in free radicals, a modification of the activity of superoxide dismutase, and the differential up-regulation of Fos gene in the hippocampus and cortex [ 26, 27].
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We explore here the effects of steroidal D-ring modification on the activity of such 2-substituted estrogen-3-O-sulfamates in respect of inhibition of tumour cell proliferation and steroid sulphatase.
No significant modification of the activities of hypoxanthine guanine phosphoribosyl transferase, thiopurine methyltransferase or inosine monophosphate dehydrogenase was observed.
In our experiments, EOD did induced small significant changes in the activity of mitochondrial complexes II and III indicating that the effect of EOD on mitochondrial activity may be due to modifications of the activity of mitochondrial complexes but not by changes in the amount of these complexes.
Modifications of the activity of antioxidant enzymes were also observed at that level.
In order to determine if modifications of the expression of lipogenic genes is accompanied by parallel modifications of the activity of the lipogenic pathway we measured in most experiments this activity by determining the incorporation of deuterium from deuterated water into the palmitate of cellular TG [ 28].
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modification of the implementation
alterations of the activity
modification of the operational
modifications of the activity
changes of the activity
modification of the glycosyl
modification of the code
modification of the tandem
modification of the method-II
modification of the algorithm
modification of the method
modification of the car
modification of the execution
modification of the estimation
modification of the catalyst
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