Indeed, studies suggest that mammalian cells have developed other ways of controlling stress granule assembly, primarily through posttranslational modifications of stress granule proteins (Anderson and Kedersha, 2009; Buchan and Parker, 2009; Kedersha et al., 2013; Wippich et al., 2013).
It is based on, and is a modification of, the stress and strain potentials for the mode III crack in an elastic solid.
Thus, RNF5 overexpression is expected to impair the ER stress response, consistent with the modification of ER stress associated chaperones observed in our mouse model.
A comparison of our reports suggests that the modification of the stress treatment may depend on the genetic background of the host animals, the baseline structure of the microbiota and the stress treatment protocols employed.
It was found that the orientation produced by deformation process is controlled entirely by the strain applied to the material, while the differences induced by modification of the stress due to the change of the deformation temperature are of minor consequence.
An important downstream mechanism whereby FOXO3A might influence human aging is through modification of oxidative stress.
Modification of oxidative stress by co-treatment with pharmacologic modulators of reactive oxygen species attenuated cytotoxicity of paclitaxel.
A modification of nominal stresses – e.g. by the use of an appropriate stress concentration factor kf – is therefore required in order to obtain safe joint designs with respect to fatigue.
