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In addition, we observed a modification of stage composition of prf-iKO parasites depleted in PRF in peripheral blood, with a decreased proportion of ring stages and the appearance of circulating mature segmented schizonts.
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Modifications of staging systems for hilar cholangiocarcinoma in order to enhance prognostic accuracy have recently been proposed [ 5, 6].
More recent modifications of staging subdivide stage 3 into stage 3A (<60 and >45 ml/min/1.73m) and stage 3B (<45 and >30 ml/min/1.73m) and take into consideration the degree of proteinuria.
Several authors have addressed the magnitude of the impact of the modifications on stage grouping.
Inclusion criteria were women in postmenopausal status, which was defined as cessation of menses for at least 1 year in accordance with the recent ReSTAGE's modification of the Stages of Reproductive Aging Workshop (STRAW) staging criteria [ 10].
Dukes A and B cancers were classed as early, Dukes C cancers as regional and Dukes D cancers as advanced according to the Turnbull modification of Dukes staging (Dukes, 1932).
Staging was based on Musshoff modification of the Ann Arbor staging system.
On the foundation of these results, we suggest a modification of the TNM staging classification that is based on LND instead of pN stage for patients with nodal metastases.
Staging of disease is performed according to the Cotswold modification of the Ann Arbor staging system (Table 1).
The staging and classification of lesions were based on the Musshoff modification of the Ann Arbor staging system.
This is an an extension and modification of the six-stage process proposed by Margules and Pressey (2000).
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