Sentence examples for modification of regulatory from inspiring English sources

Along the way, combinatorial gene expression control through modification of regulatory element offered tremendous opportunity for fine-tuning gene expression and generating digital-like genetic circuits.

Although rapid progress has been made in identifying multiple mechanisms that modulate p-glycoprotein action, still much more remains to be discovered, including practical aspects of inhibitor development, modification of regulatory pathways or development of specific delivery systems to lower the barrier function in brain capillaries.

These data indicated that NaB treatment did not influence splicing via altered expression or modification of regulatory proteins.

This pattern could result from the gain or modification of regulatory regions bringing about novel expression patterns.

Mechanisms have been observed that allow the modification of regulatory sequences without altering their function: divergence driving words and binding site turnover.

Thus, our results indicate a general disturbance in the modification of regulatory cysteines, as a consequence of a block in sulfide and persulfide oxidation.

Epigenetic modifications of regulatory genes crucial to the development of asthma-related pathophysiology have been put forth as a possible mechanistic basis of this disease [11].

MGO also causes posttranslational modifications of regulatory proteins, thereby providing a mechanism for regulation of gene expression and modifying cellular functions (Yao et al. 2007).

Thus SUMO-mediated transcription regulation not only involves covalent SUMO modification of transcription regulatory proteins, but also seems to involve SUMO modified co-regulatory proteins that show a non-covalent association at the TFBS.

The purpose of this work is to develop a novel stochastic optimization approach information guided genetic algorithm (IGA) to discover the local optima with different levels of modification of the regulatory loop and production rates.

As systems biology advances as a new paradigm of research thanks to the development of genome-scale computational tools and high-throughput experimental technologies including omics, systems metabolic engineering allowing modification of metabolic, regulatory and signaling networks of the cell at the systems-level is becoming possible.