Exact(2)
The other major change in cell phenotype observed was a modification of proliferation (Fig. 3a).
Reexpression of hMIA and simultaneous knockdown of p54nrb mRNA expression in MIA−/− mMSC resulted in no modification of proliferation despite induction of differentiation by TGF- β3.
Similar(6)
Thus, according to the model, at least for alpha-particle radiation from inhaled radon daughters, lung cancer induction over long periods of protracted irradiation appears to be dominated by radiation-induced modification of the proliferation kinetics of already-initiated cells rather than by direct radiation-induced initiation (i.e., mutation) of normal cells.
This effect was due to a large increase in their apoptosis without modification of their proliferation.
Effect modification of the proliferation associations by menopausal status was borderline statistically significant (p for interaction = 0.06).
MEHP (10−4 M) reduced the number of germ cells by increasing their apoptosis, measured by the detection of caspase-3 positive caspase-3 positivet modification of their proliferation.
However, the CaSR has also been shown to have pleiotropic actions on cells, including modification of cellular proliferation, differentiation, and apoptosis [ 18– 20].
GABA has a number of effects on the immune cells such as activation or suppression of cytokine secretion, modification of cell proliferation and GABA can even affect migration of the cells.
Related(1)
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