Sentence examples for modification of pigs from inspiring English sources

As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established.

As prerequisites for the generation of appropriate disease models by genetic engineering, pigs show suitable reproductive performance traits, a high-quality draft pig genome sequence is available, and efficient and precise techniques for the genetic modification of pigs have been established.

Genetic modification of pigs can be achieved by a variety of approaches, including pronuclear microinjection of DNA, sperm-mediated gene transfer, retroviral transduction, and somatic cell nuclear transfer (SCNT) using transfected donor cells (reviewed in [ 4, 5]).

Genetic modification of pigs by SCNT facilitated gene targeting [ 5- 7], inducible transgene expression [ 8], and the first successful examples of zinc finger nuclease mediated targeted gene modifications [ 9, 10] to generate tailored large animal models and donor animals for xenotransplantation.

In addition to genetic modification of donor pigs, it is hoped that our tolerance-inducing regimen will allow successful clinical xenotransplantation by overcoming additional xenogeneic immunological barriers.

Genetic modification of the pig has been hampered by inefficiency of homologous recombination and unavailability of pig embryonic stem cells.

Utilizing cell based transgenesis with site specific modification of the pig genome, one can be begin to modify gene function for the enhanced development of novel disease models in several research areas such as cardiovascular disease, xenotransplantation, and neurodegenerative diseases.

The completion of the pig genome assembly (Sscrofa10.2) provides a basis for understanding the epigenetic modifications of the pig genome including DNA methylation, which is another important issue in modern genetics.

And women could avoid the pain and risks of morbidity and mortality of pregnancy and childbirth by ectogenesis or xenogestation, the genetic modification of nonhuman animals, such as pigs, to carry human fetuses to term.

Although several immune barriers need to be overcome, considerable progress has been made in experimental models in recent years, largely through the increasing availability of pigs with new genetic modifications.

For the different parasitic environment of pigs and humans, adaptive modifications should have occurred.