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12 As follow-up was more up-to-date than the registration of incident cases (cases diagnosed in 2009 were not yet available for analysis), a modification of period analysis, called hybrid analysis was used.
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Hybrid analysis is a modification of the period approach that combines both cohort and period techniques (Brenner and Rachet, 2004).
A modification of the period method (Brenner and Gefeller, 1996) was used to compute 5-year relative survival ratios (RSR) of cancers diagnosed in the period 1992 2000 and deaths 1996 to 2001.
The modification of the clearance period in S4 S6 revealed that a clearance period greater than 30 days (S4), in conjunction with all other criteria, was optimal based on a combination of measures: the percentage of false negatives (2.3%), the percentage of patients with multiple fall-related hip fractures (3.2%) and accuracy estimates (between 98% and 99%).
Fig. 6 Modification of the cycle period during the data transmission phase.
Survey of the structural damages caused by earthquakes reported that the infills panels had an important contribution in the seismic response of the buildings, namely through the modification of the natural period of the structure due to the increase of the structural lateral stiffness provided.
Second, we tested here whether such prior entrainment to non-24-h light-dark cycles would lead to subsequent modification of the intrinsic period of the human circadian timing system.
Among those with sustained remission under whatever regimen, the arthritis may be more amenable to therapy – the window of opportunity opened more widely – because the immune system has not yet been permanently reconfigured (perhaps by epigenetic modification), a period of disease modifying anti-rheumatic drug treatment allowing restitution.
The role of JARID1A also extends to other areas of cellular control, with an example being modification of the circadian clock period [ 168].
Remediation of under-recruitment to avoid study closure often leads to costly changes including a re-evaluation of the sample size required, extension of the patient intake period, modification of the inclusion/exclusion criteria, and addition of new study sites [ 5].
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