Sentence examples for modification of peptide from inspiring English sources

Since no modifications of peptide structure was observed while wtEBO16 was able to induce PC vesicle aggregation and to promote vesicle leakage (data not shown), the endothermic behavior was correlated with these events, since modification of peptide structure was not observed.

The first modification of peptide with mass 1705.7642 Da is an N-terminal loss of NH3 with −17.0265 Da and cyclization of glutamine (Q) [17], while the second modification of peptide with mass 1721.7544 Da is an extra oxidation of methionine (M), which leads to an increase of the mass by 15.999 Da (net change 15.999 17.0265 ≈ −1 Da).

For the global proteomic dataset, carbamidomethylation of cysteine and iTRAQ 4-plex modification of peptide N-termini were set as fixed modifications, and oxidation of methionine and iTRAQ 4-plex modification of Lys were set as variable modifications.

Mechanism-based protease inhibitors conjugated to peptide derivatives, such as E64, or to NS2 substrate peptides have shown no inhibitory activity, suggesting the modification of peptide substrates may not be a viable route for the development of an NS2 autoprotease inhibitor.

The structure of the DiLeu isobaric labeling reagent follows that of other isobaric reagents in that it is composed of a reporter group, a balance group, and an amine-reactive group: an N, N-dimethylated leucine makes up the reporter and the balance groups, and a triazine ester amine-reactive moiety enables selective modification of peptide N-termini and lysine side chains.

Thiol-X chemistry has proven to be a valuable toolbox for modification of peptides, proteins, monomers, and polymers.

Artificial synthesis and site-specific modification of peptides and proteins has evolved into an indispensable tool for protein engineers and chemical biologists.

The quest to enlarge the molecular space of functional biomolecules has led to the discovery of selective, mild and high-yielding chemical reactions for the modification of peptides and proteins.

(Unrelated to the posttranslational modification of peptides, we have also identified the egl nine homolog-also a prolyl hydroxylase).

Furthermore, secosterol modification of peptides and proteins conveys sufficient lipophilicity to allow for hydrophobic enrichment of secosterol peptide adducts in complex mixtures.

Our design strategy demonstrates that a simple modification of peptides with an unnatural amino acid can impart remarkable in-cell stability to peptides.