Sentence examples for modification of pathway from inspiring English sources

This concept seems especially valuable for efficient amino acid production, demanding for a global modification of pathway fluxes – a challenge with regard to the high complexity of the underlying metabolism, superimposed by various layers of metabolic and transcriptional control.

The first step identifies candidate driver pathways using a mutational pathway enrichment analysis, based on a modification of Pathway Enrichment Analysis (PWEA) developed previously in our Lab [ 19].

Data from studies that measured cancer incidences associated with epigenetic modification of pathway genes and/or alterations in protein or mRNA levels were also included.

Although much attention has been paid to metabolic engineering with some practical success, without profound insight into metabolic regulation, the modification of pathways based on the knockout of corresponding genes and/or amplification by plasmids does not necessarily lead to a significant improvement in cell growth and/or the production of specific metabolites.

There have been some antithrombotic substances in the past, however, which have shown to induce a prothrombotic state through modification of pathways which differ from those who are primarily targeted, with the consequence of increasing adverse clinical events [ 20].

Comparative analysis of completely sequenced genomes can be used to reveal the frequency and distribution of SNPs, and the conservation of gene arrangements, e.g., presence of introns or overlapping transcripts, functional gains by tandem duplications or modifications of pathways by specific gene losses.

Like phosphorylation, ubiquitin modification of Wnt pathway proteins has emerged as a key mechanism that determines the pathway activity.

Each method is a modification of existing pathway analysis techniques, enabling us to test an individual tumor sample's pathway aberrance by using the nRef.

Both reconstitution of omega-3 LC-PUFA biosynthetic pathways and modification of existing pathways in microorganisms have demonstrated the potential to produce high levels of omega-3 LC-PUFAs.

This network-wide strategy is in contrast with traditional metabolic engineering approaches, that entail direct modification of the pathway(s) at stake, and opens new avenues for the targeted modulation of central catabolic pathways at the transcriptional level.

This work provides useful information for the modification of metabolic pathway to improve succinate production.