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Interestingly, this belief seemed to underpin a reluctance to refer to self-management programmes, with GPs not identifying OA a chronic disease with the same standing as diabetes, but as a condition with little or no opportunity for modification of outcomes [ 36].
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The effects of these classes of genetic modification on outcome are summarized in Table 4.
Logistic regression models and variance analyses will be used to determine the impact/effect modification of secondary outcomes and to control for possible differences between the groups.
The baseline characteristics, frequency of identified etiologic diagnosis and therapeutic modification based on the diagnosis were then compared between survivors and non-survivors to evaluate the effect of therapeutic modification on outcome.
However, modification of validated outcome measures can be fraught with problems [ 24], and therefore it may be more advisable to use an outcome tool that considers the modifying effect of aids and assistance on disability.
There have been essentially no investigations that directly compare acute proton and photon effects on normal lung tissue and possible modification of the outcome due to low-dose/low-dose-rate (LDR) γ-ray pre-exposure.
Modification of air pollution associated outcomes by sex is biologically plausible, given that some studies have shown greater fractions of deposition for inhaled particles among women (Bennett et al. 1996; Jaques and Kim 2000; Kim and Hu 1998).
As no RCT was available on ACT-based interventions for cardiac patients, at the time of the study design we were not able to predict the modification of these four outcome variables as effect of the intervention.
CXCL5 genotype is associated with outcomes after ACS with potential statin modification of this effect.
Quality assessment was completed by the two independent reviewers (SC, RG), using a modification of the CanChild Outcome Measures Rating Form and Guidelines [ 13, 14], an assessment scale that evaluates the psychometric properties and clinical utility of outcome measures (Appendix A).
Interestingly, we did not observe consistent stronger temperature effects of modification for the majority of outcomes in the elderly (Table 5).
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