Sentence examples for modification of mice from inspiring English sources

Breeding and genetic modification of mice were carried out under UK Home Office license and with the approval of the Animal Welfare and Ethical Review Body at the University of Leeds.

To this end, a number of animal models have been created by exposing the immature lung to injuries induced by hyperoxia, mechanical stretch, and inflammation and most recently by the genetic modification of mice.

A prominent example is the genetic modification of mice to develop human cystic fibrosis in the early 1990s.

No differences in isoform expression of tropomyosin, myosin heavy chain, essential and regulatory myosin light chains (MLC), TnI, or in posttranslational modifications of mouse cTnT, cTnI, or regulatory MLC were observed.

While changes in Cu isotopes can clearly be related to the loss of metal binding to the protein, the change in Zn isotopes is only consistent with a genetic modification of the mice involving the PrP gene.

The experimenter counting the cells was blinded to the genotype and experimental modification of the mice.

Using a slight modification of the mouse model described above (see Materials and Methods), the C57BL/6 mice were infected with 1 × 10 CFU of H. influenzae and treated by inhaling PBS with or without 50 μM beclomethasone.

This means it requires a light touch, but no major modification of my mousing style was required to use it.

An important question that arises each time when a modification of the mouse genome shows a phenotype is whether the insertion site contributes to the observed phenotype.

Both of these measures would involve modifications of the mice code.

The creation of knockout mice involves the modification of the genome of mouse embryonic stem (ES) cells through a variety of processes including homologous recombination or other mutagenic procedures [1].